Is depression caused by an imbalance of neurotransmitters or just correlated with the imbalance?

Dr. Michael Lovich

Answered May 7, 2020

No, neurotransmitter quantity have little to do with most clinical presentations. Levels of neurotransmitters in any urinary neurotransmitter test holds little to no value at all, please don’t waste your money on these.

Depression happens with trans-neuronal degeneration (TND) in areas of the brain as subsequent anaerobic respiration following energy-linked glutamate excitotoxicity. In short, the experience of depression you have can change depending on the part of the brain undergoing TND.

While “emotional stressors and life experiences” can be involved, and are a little too easy and vague to have real concrete credibility to create any action plan around, following neurophysiological function can be really helpful in mood stabilization.

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